上海 外菜 vx

您好,欢迎来到YEASEN!
400-6111-883
| |
400-6111-883
Recombinant Rhesus SAA1
产品货号:92540ES10
产品规格:10 μg
产品价格:¥ 1855.00
类别:细胞因子

说明书下载

  • Product Information

     

    Product Name

    Cat#

    Size

    Price¥

    Recombinant Rhesus Macaque Serum Amyloid A1 (Rhesus Macaque SAA1)

    92540ES10

    10 μg

    1855.00

    92540ES60

    100 μg

    8755.00

    92540ES76

    500 μg

    23085.00

     

    Product Description

     

    Serum Amyloid A protein-1 belongs to the SAA family of apolipoproteins that circulates in association with high-density lipoproteins (HDL). Mature mouse SAA1 shares 72%, 72% and 67% amino acid (aa) sequence identity with human, rabbit and equine SAA1, respectively. SAA1 and SAA2 share 113 of their 122 amino acids and are termed ASAA (acute phase SAA). SAA1 is produced in the liver in both human and mouse. SAA1 is prominently produced in human adipose tissue, but is absent in mouse adipose, which instead expresses adipose SAA3 (a pseudogene in humans). SAA1 is a ligand for CD36/SRB3, SRB1, FPRL1, TLR2, and RAGE on monocytes/macrophages, inducing chemotaxis and generation of cytokines and tissue factor. SAA1 can bind the surface of invading gramnegative bacteria, acting as an opsonin to aid clearance by macrophages. SAA1 also binds platelets, probably by engaging fibrinogen on the platelet surface.

     

    Product Properties

     

    Synonyms

    MGC111216, PIG4, SAA, SAA1, SAA2, serum amyloid A protein, Serum Amyloid A1, TP53I4

    Accession

    GeneID

    Source

    E.coli-derived rhesus macaque SAA1 protein, Arg19-Tyr122.

    Molecular Weight

    Approximately 11.7 kDa.

    AA Sequence

    RSWFSFLGEA YDGARDMWRA YSDMKEANYK NSDKYFHARG NYDAAQRGPG GVWAAEVISD ARENIQKLLG RGAEDTLADQ AANEWGRSGK DPNHFRPAGL PEKY

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    >97% by SDS-PAGE and HPLC analyses.

    Biological Activity

    The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100 ng/mL. Fully biologically active when compared to standard.

    Endotoxin

    < 1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20. Further dilutions should be made in appropriate buffered solutions.

     

    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20℃ to -80 for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.


    Cautions

     

    1. Avoid repeated freeze-thaw cycles.

    2. For your safety and health, please wear lab coats and disposable gloves for operation.

    3. For research use only!

     

    HB220428