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400-6111-883
Recombinant Mouse I-TAC/CXCL11 (Mouse I-TAC/CXCL11)
产品货号:90928ES08
产品规格:5 μg
产品价格:¥ 815.00
类别:细胞因子

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  • Product Information

     

    Product Name

    Cat#

    Size

    Price(¥

    Recombinant Mouse I-TAC/CXCL11 (Mouse I-TAC/CXCL11)

    90928ES08

    5 μg

    815.00

    90928ES60

    100 μg

    7865.00

    90928ES76

    500 μg

    20425.00

     

    Product Description

     

    CXCL11 also known as I-TAC is belonging to the CXC chemokine family. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 (Crg-2) and mouse MIG, respectively. CXCL11 binds CXCR3 with a higher affinity than CXCL10, suggesting that CXCL11 has the potential to restrain inflammatory autoimmunity. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.CXCL11 is not only a major effector for T cell chemotaxis in the pathophysiology of neuroinflammatory disorders, but also plays a crucial role in migration of activating T cells during IFN-dominated immune responses.

     

    Product Properties

     

    Synonyms

    beta-R1, b-R1, chemokine (C-X-C motif) ligand 11, CXCL11, H174, H174IP9, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, ITAC

    Accession

    GeneID

    Source

    E.coli-derived mouse I-TAC/CXCL11 protein, Phe22-Met100.

    Molecular Weight

    Approximately 9.1 kDa.

    AA Sequence

    FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    >98% by SDS-PAGE and HPLC analyses.

    Biological Activity

    The biological activity determined by a chemotaxis bioassay using mouse CXCR3 transfected 293 cells is in a concentration of 10-100 ng/mL. Fully biologically active when compared to standard.

    Endotoxin

    < 1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM Sodium Citrate, pH 4.0, with 600 mM NaCl.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

     

    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20 to -80 for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.


     

    Cautions

     

    1. Avoid repeated freeze-thaw cycles.

    2. For your safety and health, please wear lab coats and disposable gloves for operation.

    3. For research use only!

     

    HB220406