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400-6111-883
Recombinant Mouse Interleukin-9 (Mouse IL-9)
产品货号:90148ES10
产品规格:10 μg
产品价格:¥ 1855.00
类别:细胞因子

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  • Product Information

     

    Product Name

    Cat#

    Size

    Price(¥

    Recombinant Mouse Interleukin-9 (Mouse IL-9)

    90148ES10

    10 μg

    1855.00

    90148ES60

    100 μg

    13615.00

    90148ES76

    500 μg

    35395.00

     

    Product Description

     

    Interleukin-9 (IL-9), also known as P40 and MEA (mast cell growth-enhancing activity), is a 30-40 kDa glycosylated member of a cytokine family that includes Interleukins-2, -4, -7, -15, and -21. These proteins utilize heteromeric receptors containing the Common gamma chain ( gamma c) in addition to ligand-specific subunits. IL-9 interacts selectively with IL-9 R which then associates with gamma c to form the functional receptor complex. IL-9 contributes to allergic inflammation, autoimmunity-induced inflammation, parasite clearance from the GI tract, and Treg-mediated immune suppression. It enhances the expansion and recruitment of mast cells and eosinophils as well as the production of IgE and Th2 cytokines. It is required for anaphylactic responses to ingested allergens but not to systemic allergens. IL-9 plays multiple roles in the development and function of subsets within the CD4+ T cell lineage. It is expressed by activated Th9, Th17, Treg, and Th2 cells. IL-9 acts as an autocrine growth and activation factor for Th17, Treg, and mast cells. It also can inhibit immune responses by enhancing the suppressive properties of Treg and by recruiting immune-suppressive mast cells to sites of inflammation. Mature mouse IL-9 shares 57% and 74% amino acid sequence identity with human and rat IL-9, respectively.

     

    Product Properties

     

    Synonyms

    Cytokine P40, T-cell Growth Factor P40

    Accession

    GeneID

    16198

    Source

    E.coli-derived Mouse IL-9, Gln19-Pro144.

    Molecular Weight

    Approximately 14.2 kDa.

    AA Sequence

    QRCSTTWGIR DTNYLIENLK DDPPSKCSCS GNVTSCLCLS VPTDDCTTPC YREGLLQLTN ATQKSRLLPV FHRVKRIVEV LKNITCPSFS CEKPCNQTMA GNTLSFLKSL LGTFQKTEMQ RQKSRP

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    > 97% by SDS-PAGE and HPLC analyses.

    Biological Activity

    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine TS1 cells is less than 0.02 ng/mL, corresponding to a specific activity of > 5.0 × 107 IU/mg.

    Endotoxin

    0.1 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.


    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

     

    Cautions

     

    1. Avoid repeated freeze-thaw cycles.

    2. For your safety and health, please wear lab coats and disposable gloves for operation.

    3. For research use only.

     

    HB220402