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400-6111-883
Recombinant Exendin-4 ( Exendin-4)
产品货号：92552ES60
产品规格：100 μg
产品价格：¥ 935.00
类别：细胞因子

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  • Product Information

     

    Product Name

    Cat#

    Size

    Price（¥）

    Recombinant Exendin-4 ( Exendin-4)

    92552ES60

    100 μg

    935.00

    92552ES76

    500 μg

    2635.00

     

    Product Description

     

    Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

     

    Product Properties

     

    Synonyms

    Exenatide

    Accession

    GeneID

      

    Source

    E.coli-derived Exendin-4

    Molecular Weight

    Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.

    AA Sequence

    HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    > 96 % by SDS-PAGE and HPLC analyses.

    Biological Activity

    1. Regulates Glucose levels rapidly;
    2. Reduces Insulin resistance;
    3. Reduces Glucagon;
    4. Reduces HbA1c;
    5. Stimulates beta cell growth which stimulates insulin production.

    Endotoxin

    < 10 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

     

    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

     

    Cautions

     

    Avoid repeated freeze-thaw cycles.

    For your safety and health, please wear lab coats and disposable gloves for operation.

    For research use only!

     

    HB220302