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Recombinant Human Neutrophil Activating Protein-2/CXCL7 (Human NAP-2/CXCL7)
产品货号：90910ES10
产品规格：10 μg
产品价格：¥ 1855.00
类别：细胞因子

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  • Product Information

     

    Product Name

    Cat#

    Size

    Price（¥）

    Recombinant Human Neutrophil Activating Protein-2/CXCL7 (Human NAP-2/CXCL7)

    90910ES10

    10 μg

    1855.00

    90910ES60

    100 μg

    7865.00

    90910ES76

    500 μg

    20425.00

     

    Product Description

     

    Neutrophil Activating Peptide 2 (NAP-2), also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and Pro-platelet basic protein (PPBP), is a member of the CXC chemokines. NAP-2 is found in the alpha-granules of human platelets. Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR2 and to chemoattract and activate neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63).

     

    Product Properties

     

    Synonyms

    CXCL7, LDGF, MDGF, Small-inducible cytokine B7

    Accession

    P02775

    GeneID

    5473

    Source

    E.coli-derived Human NAP-2/CXCL7, Ala59-Asp128.

    Molecular Weight

    Approximately 7.6 kDa.

    AA Sequence

    AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    > 97% by SDS-PAGE and HPLC analyses.

    Biological Activity

    The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/mL. Fully biologically active when compared to standard.

    Endotoxin

    < 1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 50 mM NaCl.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.

     

    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

     

    Cautions

     

    Avoid repeated freeze-thaw cycles.

    For your safety and health, please wear lab coats and disposable gloves for operation.

    For research use only!

     

    HB220225