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400-6111-883
Recombinant Human Bone Morphogenetic Protein 7 (Human BMP-7)
产品货号:92054ES10
产品规格:10 μg
产品价格:¥ 1855
类别:细胞因子

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  • Product Information

     

    Product Name

    Cat#

    Size

    Price(¥

    Recombinant Human Bone Morphogenetic Protein 7 (Human BMP-7)

    92054ES10

    10 μg

    1855.00

    92054ES60

    100 μg

    13615.00

    92054ES76

    500 μg

    35395.00

     

    Product Description

     

    BMP-7 is a member of the TGF-β superfamily which is supposed to be one of the most potent anabolic factors of chondrocytes. The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development, inhibits the branching of prostate epithelium, and antagonizes epithelial-mesenchymal transition (EMT). Bone morphogenetic protein (BMP) signaling regulates a range of cellular processes and plays an important role in the specification and patterning of the early embryo. BMP-7 expression is known to be protective for renal damage during diabetic nephropathy and disappears early during the progression of diabetic nephropathy. The clinical application of BMP7 is based on its neuroprotective role in stroke animal models.

     

    Product Properties

     

    Synonyms

    BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, OP-1, Osteogenic protein 1

    Accession

    GeneID

    655

    Source

    E.coli-derived human BMP-7, Ser293-His431.

    Molecular Weight

    Approximately 15.7 kDa.

    AA Sequence

    STGSKQRSQN RSKTPKNQEA LRMANVAENS SSDQRQACKK HELYVSFRDL GWQDWIIAPE GYAAYYCEGE CAFPLNSYMN ATNHAIVQTL VHFINPETVP KPCCAPTQLN AISVLYFDDS SNVILKKYRN MVVRACGCH

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    >95% by SDS-PAGE and HPLC analyses.

    Biological Activity

    Testing in progress

    Endotoxin

    1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in 30 % acetonitrile, 0.1% TFA..

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10 mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

     

    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20 to -80 for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.


    Cautions

     

    Avoid repeated freeze-thaw cycles.

    For your safety and health, please wear lab coats and disposable gloves for operation.

    For research use only.

     

    HB220210