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400-6111-883
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400-6111-883
Recombinant Human IL-6
产品货号:90107ES08
产品规格:5 μg
产品价格:¥ 815
类别:细胞因子

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  • 产品信息

     

    产品名称

    产品编号

    规格

    价格(元)

    Recombinant Human Interleukin-6 (Human IL-6)

    90107ES08

    5 μg

    815.00

    Recombinant Human Interleukin-6 (Human IL-6)

    90107ES60

    100 μg

    7865.00

    Recombinant Human Interleukin-6 (Human IL-6)

    90107ES76

    500 μg

    20425.00

     

    产品描述

     

    Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation. IL-6 is a pleiotropic, alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6. It also induces myeloma and plasmacytoma growth. And it is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs. In a target cell, IL-6 can simultaneously generate functionally distinct or sometimes contradictory signals through its receptor complex, IL-6Ralpha and gp130.

     

    产品性质

     

    Synonyms

    Interleukin-6, IL-6, B-cell differentiation factor, B-cell stimulatory factor 2, BSF2; BSF-2, CDF, CTL differentiation factor, HSF, IFNB2, IFN-beta-2, Interferon beta-2, interleukin BSF-2, MGI-2A.

    Accession

    GeneID

    Source

    E.coli-derived human IL-6 protein, Val30-Met212.

    Molecular Weight

    Approximately 20.8 kDa.

    AA Sequence

    VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    > 96 % by SDS-PAGE and HPLC analyses.

    Biological Activity

    The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 1.0 × 107 IU/mg. Fully biologically active when compared to standard.
    2. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine T1165 cells is less than 0.8 ng/ml, corresponding to a specific activity of > 1.25 × 106 IU/mg. Fully biologically active when compared to standard.

    Endotoxin

    < 1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20. Further dilutions should be made in appropriate buffered solutions.


    运输与保存方法

     

    常温运输-20℃至-80℃长期存,一年有效建议第一次使用时分装冻存,避免反复冻融。

     

    注意事项

     

    避免反复冻融。

    为了您的安全和健康,请穿实验服并戴一次性手套操作。

    本产品仅作科研用途!

     

    HB220125